Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses.

Engfer, Zachary J; Lewandowski, Dominik; Dong, Zhiqian; Palczewska, Grazyna; Zhang, Jianye; Kordecka, Katarzyna; Placzkiewicz, Jagoda; Panas, Damian; Foik, Andrzej T; Tabaka, Marcin; Palczewski, Krzysztof

Engfer, Zachary J; Lewandowski, Dominik; Dong, Zhiqian; Palczewska, Grazyna; Zhang, Jianye; Kordecka, Katarzyna; Placzkiewicz, Jagoda; Panas, Damian; Foik, Andrzej T; Tabaka, Marcin; Palczewski, Krzysztof.

Afiliação

Engfer ZJ; Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA 92697.
Lewandowski D; Department of Physiology and Biophysics, University of California, Irvine, CA 92697.
Dong Z; Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA 92697.
Palczewska G; Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA 92697.
Zhang J; Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA 92697.
Kordecka K; Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA 92697.
Placzkiewicz J; Ophthalmic Biology Group, International Centre for Translational Eye Research, Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw 01-224, Poland.
Panas D; Ophthalmic Biology Group, International Centre for Translational Eye Research, Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw 01-224, Poland.
Foik AT; International Centre for Translational Eye Research, Warsaw 01-224, Poland.
Tabaka M; Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw 01-224, Poland.
Palczewski K; Ophthalmic Biology Group, International Centre for Translational Eye Research, Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw 01-224, Poland.

Proc Natl Acad Sci U S A ; 120(50): e2314698120, 2023 Dec 12.

Article em En | MEDLINE | ID: mdl-38064509

Assuntos

Degeneração Macular; Degeneração Retiniana; Humanos; Camundongos; Animais; Doença de Stargardt/metabolismo; Degeneração Macular/tratamento farmacológico; Degeneração Macular/genética; Degeneração Macular/metabolismo; Retinaldeído/metabolismo; Retina/metabolismo; Degeneração Retiniana/tratamento farmacológico; Degeneração Retiniana/genética; Degeneração Retiniana/metabolismo; Modelos Animais de Doenças; Transportadores de Cassetes de Ligação de ATP/genética; Transportadores de Cassetes de Ligação de ATP/metabolismo

Palavras-chave

ABCA4; Stargardt disease; ceramides; comparative pharmacology; retinal degeneration

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degeneração Retiniana / Degeneração Macular Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article

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