[A global core outcome measurement set for snakebite clinical trials]. / Définition d'un jeu universel de critères de décision de base pour les essais cliniques sur les morsures de serpent.
Med Trop Sante Int
; 3(3)2023 09 30.
Article
em Fr
| MEDLINE
| ID: mdl-38094484
ABSTRACT
Background:
Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation.Method:
A globally representative group of key stakeholders came together to reach consensus on a globally relevant set of core outcome measurements. Outcome domains and outcome measurement instruments were identified through searching the literature and a systematic review of snakebite clinical trials. Outcome domains were shortlisted by use of a questionnaire and consensus was reached among stakeholders and the patient group through facilitated discussions and voting.Results:
Five universal core outcome measures should be included in all future snakebite clinical trials mortality, WHO disability assessment scale, patient-specific functional scale, acute allergic reaction by Brown criteria, and serum sickness by formal criteria. Additional syndrome-specific core outcome measures should be used depending on the biting species.Conclusion:
This core outcome measurement set provides global standardisation, supports the priorities of patients and clinicians, enables meta-analysis, and is appropriate for use in low-income and middle-income settings.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mordeduras de Serpentes
/
Ensaios Clínicos como Assunto
Limite:
Humans
Idioma:
Fr
Revista:
Med Trop Sante Int
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Reino Unido