Lanostane triterpenoids from the fruiting bodies of Ganoderma amboinense.
Phytochemistry
; 218: 113952, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38096963
ABSTRACT
Lanostane-type triterpenoids are the main characteristic constituents in Ganoderma mushrooms. Phytochemical analysis on the ethanol extract of the fruiting bodies of Ganoderma amboinense led to isolation and identification of twelve previously undescribed lanostane triterpenoids (1-12). Their chemical structures were determined by HR-ESI-MS, IR, and NMR spectroscopic analysis, NMR calculation, as well as X-ray crystallography. All isolates were evaluated for the α-glucosidase inhibitory and anti-inflammatory activities. Compounds 1, 5, 6, and 11 showed significant α-glucosidase inhibitory activity with IC50 values ranging from 33.5 µM to 96.0 µM. Moreover, compound 12 showed anti-inflammatory activity with IC50 value of 21.7 ± 2.1 µM.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Ganoderma
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China