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FL-41 Tint Reduces Activation of Neural Pathways of Photophobia in Patients with Chronic Ocular Pain.
Reyes, Nicholas; Huang, Jaxon J; Choudhury, Anjalee; Pondelis, Nicholas; Locatelli, Elyana V T; Hollinger, Ruby; Felix, Elizabeth R; Pattany, Pradip M; Galor, Anat; Moulton, Eric A.
Afiliação
  • Reyes N; Surgical Services, Miami Veterans Administration Medical Center (N.R., J.J.H., A.C., E.V.T.L., R.H., A.G.), Miami, Florida, USA; Bascom Palmer Eye Institute, University of Miami (N.R., J.J.H., A.C., E.V.T.L., A.G.), Miami, Florida, USA.
  • Huang JJ; Surgical Services, Miami Veterans Administration Medical Center (N.R., J.J.H., A.C., E.V.T.L., R.H., A.G.), Miami, Florida, USA; Bascom Palmer Eye Institute, University of Miami (N.R., J.J.H., A.C., E.V.T.L., A.G.), Miami, Florida, USA.
  • Choudhury A; Surgical Services, Miami Veterans Administration Medical Center (N.R., J.J.H., A.C., E.V.T.L., R.H., A.G.), Miami, Florida, USA; Bascom Palmer Eye Institute, University of Miami (N.R., J.J.H., A.C., E.V.T.L., A.G.), Miami, Florida, USA.
  • Pondelis N; Brain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Department of Anesthesia (N.P., E.A.M.), Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Massachusetts, USA.
  • Locatelli EVT; Surgical Services, Miami Veterans Administration Medical Center (N.R., J.J.H., A.C., E.V.T.L., R.H., A.G.), Miami, Florida, USA; Bascom Palmer Eye Institute, University of Miami (N.R., J.J.H., A.C., E.V.T.L., A.G.), Miami, Florida, USA.
  • Hollinger R; Surgical Services, Miami Veterans Administration Medical Center (N.R., J.J.H., A.C., E.V.T.L., R.H., A.G.), Miami, Florida, USA.
  • Felix ER; Research Service, Miami Veterans Administration Medical Center (E.R.F.), Miami, Florida, USA; Physical Medicine and Rehabilitation (E.R.F.), University of Miami, Miami, Florida, USA.
  • Pattany PM; Department of Radiology (P.M.P.), University of Miami, Miami, Florida, USA.
  • Galor A; Surgical Services, Miami Veterans Administration Medical Center (N.R., J.J.H., A.C., E.V.T.L., R.H., A.G.), Miami, Florida, USA; Bascom Palmer Eye Institute, University of Miami (N.R., J.J.H., A.C., E.V.T.L., A.G.), Miami, Florida, USA.
  • Moulton EA; Brain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Department of Anesthesia (N.P., E.A.M.), Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Massachusetts, USA; Department of Ophthalmology (E.A.M.), Boston Children's Hospital, Harvard Medical
Am J Ophthalmol ; 259: 172-184, 2024 03.
Article em En | MEDLINE | ID: mdl-38101593
ABSTRACT

PURPOSE:

To assess the therapeutic effect of tinted lenses (FL-41) on photophobia and light-evoked brain activity using functional magnetic resonance imaging (fMRI) in individuals with chronic ocular surface pain.

DESIGN:

Prospective case series.

METHODS:

25 subjects from the Miami veterans affairs (VA) eye clinic were recruited based on the presence of chronic ocular pain, dry eye symptoms, and photophobia. Using a 3T MRI scanner, subjects underwent 2 fMRI scans using an event-related design based on light stimuli one scan while wearing FL-41 lenses and one without. Unpleasantness ratings evoked by the light stimuli were collected after each scan.

RESULTS:

With FL-41 lenses, subjects reported decreased (n = 19), maintained (n = 2), or increased (n = 4) light-evoked unpleasantness ratings. Group analysis at baseline (no lens) revealed significant light evoked responses in bilateral primary somatosensory (S1), bilateral secondary somatosensory (S2), bilateral insula, bilateral frontal pole, visual, precuneus, paracingulate, and anterior cingulate cortices (ACC) as well as cerebellar vermis, bilateral cerebellar hemispheric lobule VI, and bilateral cerebellar crus I and II. With FL-41 lenses, light-evoked responses were significantly decreased in bilateral S1, bilateral S2, bilateral insular, right temporal pole, precuneus, ACC, and paracingulate cortices as well as bilateral cerebellar hemispheric lobule VI.

CONCLUSION:

FL-41 lenses modulated photophobia symptoms in some individuals with chronic ocular pain. In conjunction, FL-41 lenses decreased activation in cortical areas involved in processing affective and sensory-discriminative dimensions of pain. Further research into these relationships will advance the ability to provide precision therapy for individuals with ocular pain.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Fotofobia Limite: Humans Idioma: En Revista: Am J Ophthalmol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Fotofobia Limite: Humans Idioma: En Revista: Am J Ophthalmol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos