Avian v-myc replaces chromosomal translocation in murine plasmacytomagenesis.
Science
; 235(4790): 787-9, 1987 Feb 13.
Article
em En
| MEDLINE
| ID: mdl-3810165
ABSTRACT
Deregulation of c-myc expression in association with chromosomal translocations occurs in over 95% of murine plasmacytomas, rat immunocytomas, and human Burkitt lymphomas. Infection with a murine retrovirus (J-3) containing an avian v-myc rapidly induced plasmacytomas in pristane-primed BALB/cAn mice. Only 17% of the induced plasmacytomas that were karyotyped showed the characteristic chromosomal translocations involving the c-myc locus. Instead, all of the translocation-negative tumors demonstrated characteristic J-3 virus integration sites that were actively transcribed. Thus, the high levels of v-myc expression have replaced the requirement for chromosomal translocation in plasmacytomagenesis and accelerated the process of transformation.
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Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Plasmocitoma
/
Retroviridae
/
Translocação Genética
/
Transformação Celular Neoplásica
/
Genes Virais
/
Vírus da Leucemia Murina de Moloney
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1987
Tipo de documento:
Article