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Predictors of non-adherence to antihypertensive medications: A cross-sectional study from a regional hospital in Afghanistan.
Stanikzai, Muhammad Haroon; Wafa, Mohammad Hashim; Tawfiq, Essa; Jafari, Massoma; Le, Cua Ngoc; Wasiq, Abdul Wahed; Rahimi, Bilal Ahmad; Baray, Ahmad Haroon; Ageru, Temesgen Anjulo; Suwanbamrung, Charuai.
Afiliação
  • Stanikzai MH; Public Health Research Program, School of Public Health, Walailak University, Thai Buri, Thailand.
  • Wafa MH; Excellent Center for Dengue and Community Public Health (EC for DACH), Walailak University, Thai Buri, Thailand.
  • Tawfiq E; Faculty of Medicine, Department of Public Health, Kandahar University, Kandahar, Afghanistan.
  • Jafari M; Faculty of Medicine, Neuropsychiatric and Behavioral science Department, Kandahar University, Kandahar, Afghanistan.
  • Le CN; The Kirby Institute, UNSW Sydney, Sydney, Australia.
  • Wasiq AW; McMaster University, Hamilton, Ontario, Canada.
  • Rahimi BA; Public Health Research Program, School of Public Health, Walailak University, Thai Buri, Thailand.
  • Baray AH; Excellent Center for Dengue and Community Public Health (EC for DACH), Walailak University, Thai Buri, Thailand.
  • Ageru TA; Faculty of Medicine, Department of Internal Medicine, Kandahar University, Kandahar, Afghanistan.
  • Suwanbamrung C; Department of Pediatrics, Faculty of Medicine, Kandahar University, Kandahar, Afghanistan.
PLoS One ; 18(12): e0295246, 2023.
Article em En | MEDLINE | ID: mdl-38150430
ABSTRACT

BACKGROUND:

Non-adherence to antihypertensive medications (AHMs) is a widespread problem. Cardiovascular morbidity and mortality reduction is possible via better adherence rates among hypertensive patients.

OBJECTIVES:

This study aimed to assess the prevalence of non-adherence to AHMs and its predictors among hypertensive patients who attended Mirwais Regional Hospital in Kandahar, Afghanistan.

METHODS:

A cross-sectional study using random sampling method was conducted among hypertensive patients, aged ≥18 years in Mirwais Regional Hospital at a 6-month follow-up between October and December 2022. To assess non-adherence to AHMs, we employed the Hill-Bone Medication Adherence scale. A value below or equal to 80% of the total score was used to signify non-adherence. A multivariable binary logistic regression model was used to identify predictors of non-adherence to AHMs.

RESULTS:

We used data from 669 patients and found that 47.9% (95%CI 44.1-51.8%) of them were non-adherent to AHMs. The majority (71.2%) of patients had poorly controlled blood pressure (BP). The likelihood of non-adherence to AHMs was significantly higher among patients from low monthly-income households [Adjusted odds ratio (AOR) 1.70 (95%CI 1.13-2.55)], those with daily intake of multiple AHMs [AOR 2.02 (1.29-3.16)], presence of comorbid medical conditions [AOR 1.68 (1.05-2.67), lack of awareness of hypertension-related complications [AOR 2.40 (1.59-3.63)], and presence of depressive symptoms [AOR 1.65 (1.14-2.38)].

CONCLUSION:

Non-adherence to AHMs was high. Non-adherence to AHMs is a potential risk factor for uncontrolled hypertension and subsequent cardiovascular complications. Policymakers and clinicians should implement evidence-based interventions to address factors undermining AHMs adherence in Afghanistan.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipertensão / Anti-Hipertensivos Limite: Adolescent / Adult / Humans País/Região como assunto: Asia Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Tailândia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipertensão / Anti-Hipertensivos Limite: Adolescent / Adult / Humans País/Região como assunto: Asia Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Tailândia