Reproductive Profile of Neuronal Androgen Receptor Knockout Female Mice With a Low Dose of DHT.
Endocrinology
; 165(3)2024 Jan 16.
Article
em En
| MEDLINE
| ID: mdl-38156784
ABSTRACT
Hyperandrogenism and polycystic ovarian syndrome result from the imbalance or increase of androgen levels in females. Androgen receptor (AR) mediates the effects of androgens, and this study examines whether neuronal AR plays a role in reproduction under normal and increased androgen conditions in female mice. The neuron-specific AR knockout (KO) mouse (SynARKO) was generated from a female mouse (synapsin promoter driven Cre) and a male mouse (Ar fl/y). Puberty onset and the levels of reproductive hormones such as LH, FSH, testosterone, and estradiol were comparable between the control and the SynARKO mice. There were no differences in cyclicity and fertility between the control and SynARKO mice, with similar impairment in both groups on DHT treatment. Neuronal AR KO, as in this SynARKO mouse model, did not alleviate the infertility associated with DHT treatment. These studies suggest that neuronal AR KO neither altered reproductive function under physiological androgen levels, nor restored fertility under hyperandrogenic conditions.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
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Androgênios
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Endocrinology
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos