Mitochondrial lipid dynamics regulated by MITOL-mediated ubiquitination.
J Biochem
; 175(3): 217-219, 2024 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-38156789
ABSTRACT
Mitochondria-endoplasmic reticulum (ER) contact sites in mammals provide platforms for various reactions, such as calcium signaling, lipid metabolism, organelle dynamics and autophagy. To fulfill these tasks, a number of proteins assemble at the contact sites including MITOL/MARCHF5, a critical mitochondrial ubiquitin ligase. How MITOL regulates mitochondrial function from the contact site, however, has been largely unresolved. Recently, a new role for MITOL in the active transport of phosphatidic acid from the ER to mitochondria was reported. In this commentary, we briefly summarize our current understanding of mitochondria-ER contact sites and discuss the recently elucidated mechanism of MITOL fine-tuning phospholipid transfer activity through ubiquitination.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Mitocôndrias
Limite:
Animals
Idioma:
En
Revista:
J Biochem
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão