Serum expression levels of selected microRNAs and their association with glucose metabolism in young women with polycystic ovary syndrome.
Pol Arch Intern Med
; 134(1)2024 01 29.
Article
em En
| MEDLINE
| ID: mdl-38164524
ABSTRACT
INTRODUCTION:
Polycystic ovary syndrome (PCOS) is associated with metabolic disturbances, such as insulin resistance and prediabetes, and the risk for their occurrence is especially increased in hyperandrogenic (HA) phenotypes of PCOS. Circulating microRNAs (miRNAs) may be involved in PCOS pathogenesis and regulation of metabolic processes.OBJECTIVES:
The aim of the study was to assess expression levels of selected circulating miRNAs in women with PCOS and to investigate the relationship of these miRNAs with glucose metabolism. PATIENTS ANDMETHODS:
The study included 95 patients with HAPCOS and 76 healthy women similar to the study group in age and body mass index. Measurements of sex hormone concentrations, oral glucose tolerance test (OGTT), and transvaginal ultrasonography were performed. Serum levels of selected miRNAs (miR27a, miR34a, miR106b, miR193b, miR181a, miR181b, and miR320) were assessed with realtime polymerase chain reaction, and their association with PCOS and glucose metabolism parameters was studied.RESULTS:
Serum levels of all studied miRNAs, except for miR34a, differed between the patients with HAPCOS and healthy women (all P <0.05). In HAPCOS, miR27a and miR320 levels correlated with fasting glucose (R = 0.33; P = 0.001 and R = -0.35; P <0.001, respectively) and insulin concentrations (R = 0.26; P = 0.01 and R = -0.23; P = 0.03, respectively). Additionally, the level of miR27a correlated with mean glucose concentration during OGTT (R = 0.26; P = 0.01). No such correlations were observed in the healthy women. In linear regression analyses, both miR27a and miR320 were associated with fasting glucose concentrations after adjustment for potentially confounding factors in the HAPCOS group only.CONCLUSIONS:
The expression profile of circulating miRNAs is altered in patients with HAPCOS. Circulating miR27a and miR320 could serve as potential biomarkers of glucose metabolism disturbances in PCOS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
/
Resistência à Insulina
/
MicroRNAs
Tipo de estudo:
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Pol Arch Intern Med
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Polônia