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All-in-one porous membrane enables full protection in guided bone regeneration.
Wu, Shuyi; Luo, Shulu; Cen, Zongheng; Li, Qianqian; Li, Luwei; Li, Weiran; Huang, Zhike; He, Wenyi; Liang, Guobin; Wu, Dingcai; Zhou, Minghong; Li, Yan.
Afiliação
  • Wu S; Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, 510055, Guangzhou, P. R. China.
  • Luo S; Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, 510055, Guangzhou, P. R. China.
  • Cen Z; Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Chemistry, Sun Yat-sen University, 510006, Guangzhou, P.R. China.
  • Li Q; Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, 510055, Guangzhou, P. R. China.
  • Li L; Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, 510055, Guangzhou, P. R. China.
  • Li W; Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, 510055, Guangzhou, P. R. China.
  • Huang Z; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080, Guangzhou, P. R. China.
  • He W; Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Chemistry, Sun Yat-sen University, 510006, Guangzhou, P.R. China.
  • Liang G; Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, 510055, Guangzhou, P. R. China.
  • Wu D; Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Chemistry, Sun Yat-sen University, 510006, Guangzhou, P.R. China. wudc@mail.sysu.edu.cn.
  • Zhou M; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080, Guangzhou, P. R. China. zhouminghong@gdph.org.cn.
  • Li Y; Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, 510055, Guangzhou, P. R. China. liy8@mail.sysu.edu.cn.
Nat Commun ; 15(1): 119, 2024 01 02.
Article em En | MEDLINE | ID: mdl-38168072
ABSTRACT
The sophisticated hierarchical structure that precisely combines contradictory mechanical and biological characteristics is ideal for biomaterials, but it is challenging to achieve. Herein, we engineer a spatiotemporally hierarchical guided bone regeneration (GBR) membrane by rational bilayer integration of densely porous N-halamine functionalized bacterial cellulose nanonetwork facing the gingiva and loosely porous chitosan-hydroxyapatite composite micronetwork facing the alveolar bone. Our GBR membrane asymmetrically combine stiffness and flexibility, ingrowth barrier and ingrowth guiding, as well as anti-bacteria and cell-activation. The dense layer has a mechanically matched space maintenance capacity toward gingiva, continuously blocks fibroblasts, and prevents bacterial invasion with multiple mechanisms including release-killing, contact-killing, anti-adhesion, and nanopore-blocking; the loose layer is ultra-soft to conformally cover bone surfaces and defect cavity edges, enables ingrowth of osteogenesis-associated cells, and creates a favorable osteogenic microenvironment. As a result, our all-in-one porous membrane possesses full protective abilities in GBR.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regeneração Óssea / Membranas Artificiais Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regeneração Óssea / Membranas Artificiais Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article