Preparation of [1'-13 C]citric acid as a probe in a breath test to evaluate tricarboxylic acid cycle flux.
J Labelled Comp Radiopharm
; 67(3): 86-90, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38171549
ABSTRACT
[1'-13 C]Citric acid (1) was efficiently prepared from dimethyl 1,3-acetonedicarboxylate in two steps as a probe for a breath test. The synthetic method was selected because of the yield and reproducibility. Compound 1 was orally administrated to rats, and the time course of the increase of 13 CO2 /12 CO2 ratios (Δ13 CO2 ) in their breath was successfully followed, indicating the metabolism of 1. Thus, the 13 C-breath test using 1 is a promising method to evaluate tricarboxylic acid (TCA) cycle flux.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ciclo do Ácido Cítrico
/
Ácido Cítrico
Limite:
Animals
Idioma:
En
Revista:
J Labelled Comp Radiopharm
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão