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[Analysis of advanced fibrosis in metabolic dysfunction-associated fatty liver disease patients with chronic hepatitis B].
Wu, X; Li, P; Mi, Y Q.
Afiliação
  • Wu X; Department of Gastroenterology, Department Two of Traditional Chinese and Western Medical Liver Disease, Tianjin Hepatopathy Research Institute,Tianjin Second People's Hospital, Tianjin 300192, China.
  • Li P; Department of Gastroenterology, Department Two of Traditional Chinese and Western Medical Liver Disease, Tianjin Hepatopathy Research Institute,Tianjin Second People's Hospital, Tianjin 300192, China.
  • Mi YQ; Department of Gastroenterology, Department Two of Traditional Chinese and Western Medical Liver Disease, Tianjin Hepatopathy Research Institute,Tianjin Second People's Hospital, Tianjin 300192, China.
Zhonghua Nei Ke Za Zhi ; 63(1): 53-58, 2024 Jan 01.
Article em Zh | MEDLINE | ID: mdl-38186118
ABSTRACT

Objective:

To investigate the clinical and pathological characteristics of chronic hepatitis B (CHB) with metabolic dysfunction-associated fatty liver disease (MAFLD), as well as associations with advanced fibrosis.

Methods:

CHB patients who underwent liver biopsy at Tianjin Second People's Hospital from June 2016 to September 2019 were included in the study. The patients were divided into two groups based on whether they had concomitant MAFLD; a CHB group and a MAFLD-CHB group. t-tests and Chi-square tests were used to compare pathological characteristics and basic features in the two groups. Logistic regression analysis was used to analyze factors associated with advanced fibrosis.

Results:

The CHB group included 110 patients, and the MAFLD-CHB group included 272 patients. There were significant differences in smoking, alcohol consumption, hypertension incidence, body metabolic index, alanine aminotransferase, gamma-glutamyl transferase (GGT), high-density lipoprotein, low-density lipoprotein, fasting plasma glucose, and platelets (PLT) between the two groups (all P<0.05). The MAFLD-CHB group had a higher incidence of advanced fibrosis than the CHB group (P<0.05). In logistic regression analysis MAFLD [odds ratio (OR)=2.204, 95% confidence interval (CI) 1.018-4.774, P=0.045], GGT (OR=1.008, 95%CI 1.002-1.013, P=0.005), and PLT (OR=0.995, 95%CI 0.991-0.999, P=0.019) were associated with advanced fibrosis (all P<0.05). In the MAFLD-CHB group type 2 diabetes (OR=3.281, 95%CI 1.375-7.832, P=0.007), GGT (OR=1.011, 95%CI 1.003-1.018, P=0.005), and PLT (OR=0.993, 95%CI 0.988-0.998, P=0.004) were associated with advanced fibrosis (P<0.05).

Conclusion:

Patients with MAFLD-CHB are more likely to develop advanced fibrosis than patients with CHB alone. In the MAFLD-CHB group type 2 diabetes mellitus was associated with advanced fibrosis. It is important to strictly control relevant risk factors in MAFLD-CHB patients, especially in patients with type 2 diabetes.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatite B Crônica / Diabetes Mellitus Tipo 2 / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: Zh Revista: Zhonghua Nei Ke Za Zhi Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatite B Crônica / Diabetes Mellitus Tipo 2 / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: Zh Revista: Zhonghua Nei Ke Za Zhi Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China