Impact of Clonal Heterogeneity in Multiple Myeloma.

Schinke, Carolina; Rasche, Leo; Raab, Marc S; Weinhold, Niels

Schinke, Carolina; Rasche, Leo; Raab, Marc S; Weinhold, Niels.

Afiliação

Schinke C; Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Rasche L; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany; Mildred Scheel Early Career Center (MSNZ), University Hospital of Würzburg, Würzburg, Germany.
Raab MS; Department of Internal Medicine V, Heidelberg University Clinic Hospital, Heidelberg, Germany.
Weinhold N; Department of Internal Medicine V, Heidelberg University Clinic Hospital, Heidelberg, Germany. Electronic address: niels.weinhold@med.uni-heidelberg.de.

Hematol Oncol Clin North Am ; 38(2): 461-476, 2024 Apr.

Article em En | MEDLINE | ID: mdl-38195308

ABSTRACT

ABSTRACT

Multiple myeloma is characterized by a highly heterogeneous disease distribution within the bone marrow-containing skeletal system. In this review, we introduce the molecular mechanisms underlying clonal heterogeneity and the spatio-temporal evolution of myeloma. We discuss the clinical impact of clonal heterogeneity, which is thought to be one of the biggest obstacles to overcome therapy resistance and to achieve cure.

Assuntos

Mieloma Múltiplo; Humanos; Mieloma Múltiplo/genética; Mieloma Múltiplo/terapia; Medula Óssea; Evolução Clonal/genética

Palavras-chave

Clonal heterogeneity; Evolution; Microenvironment; Myeloma; Relapse

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mieloma Múltiplo Limite: Humans Idioma: En Revista: Hematol Oncol Clin North Am Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

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