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Exploring Mycoplasma ovipneumoniae NXNK2203 infection in sheep: insights from histopathology and whole genome sequencing.
Wang, Jiandong; Liu, Hongyan; Raheem, Abdul; Ma, Qing; Liang, Xiaojun; Guo, Yanan; Lu, Doukun.
Afiliação
  • Wang J; NingXia Academy of Agricultural and Forestry Sciences, Yinchuan, 750002, China.
  • Liu H; NingXia Academy of Agricultural and Forestry Sciences, Yinchuan, 750002, China.
  • Raheem A; School of Agriculture, Ningxia University, Yinchuan, 750021, China.
  • Ma Q; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
  • Liang X; NingXia Academy of Agricultural and Forestry Sciences, Yinchuan, 750002, China.
  • Guo Y; NingXia Academy of Agricultural and Forestry Sciences, Yinchuan, 750002, China.
  • Lu D; School of Agriculture, Ningxia University, Yinchuan, 750021, China. gyn330@126.com.
BMC Vet Res ; 20(1): 20, 2024 Jan 10.
Article em En | MEDLINE | ID: mdl-38200549
ABSTRACT

BACKGROUND:

Mycoplasma ovipneumoniae (M. ovipneumoniae) is a significant pathogen causing respiratory infections in goats and sheep. This study focuses on investigating vulnerability of Hu sheep to M. ovipneumoniae infection in the context of late spring's cold weather conditions through detailed autopsy of a severely affected Hu sheep and whole genome sequencing of M. ovipneumoniae.

RESULTS:

The autopsy findings of the deceased sheep revealed severe pulmonary damage with concentrated tracheal and lung lesions. Histopathological analysis showed tissue degeneration, mucus accumulation, alveolar septum thickening, and cellular necrosis. Immunohistochemistry analysis indicated that M. ovipneumoniae was more in the bronchi compared to the trachea. Genome analysis of M. ovipneumoniae identified a 1,014,835 bp with 686 coding sequences, 3 rRNAs, 30 tRNAs, 6 CRISPRs, 11 genomic islands, 4 prophages, 73 virulence factors, and 20 secreted proteins.

CONCLUSION:

This study investigates the vulnerability of Hu sheep to M. ovipneumoniae infection during late spring's cold weather conditions. Autopsy findings showed severe pulmonary injury in affected sheep, and whole genome sequencing identified genetic elements associated with pathogenicity and virulence factors of M. ovipneumoniae.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia por Mycoplasma / Doenças dos Ovinos / Doenças das Cabras / Mycoplasma ovipneumoniae Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: BMC Vet Res Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia por Mycoplasma / Doenças dos Ovinos / Doenças das Cabras / Mycoplasma ovipneumoniae Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: BMC Vet Res Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China