Management considerations for clinically relevant findings on expanded carrier screening in a sperm donor applicant population.
F S Rep
; 4(4): 384-389, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-38204949
ABSTRACT
Objective:
To describe the clinical experience of managing expanded carrier screening (ECS) results in sperm donor applicants at a sperm bank in the United States, including considerations around suitability determination and appropriate education of prospective donors and recipients.Design:
A retrospective review of donor genetic screening records from July 2017 to December 2021.Setting:
A U.S.-based sperm bank. Patients Donor applicants at a sperm bank. Intervention Not applicable. Main OutcomeMeasures:
To examine the rate of potentially significant health risks on the basis of ECS results to inform donor management and donor/recipient counseling considerations.Results:
Nearly 2% of donor applicants were identified as having potentially significant health risks on the basis of their ECS results, and most individuals had no clinical manifestations related to these findings.Conclusion:
There are unique challenges related to ECS in third-party reproduction for gamete providers, recipients, and their healthcare providers. A collaborative, multidisciplinary approach is necessary to help mitigate risks to donor offspring and maximize patient experience. Informed consent and access to a trained genetics professional are paramount when facilitating ECS on donor applicants and disseminating results to recipients.
Texto completo:
1
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Idioma:
En
Revista:
F S Rep
Ano de publicação:
2023
Tipo de documento:
Article