Reprograming of transcriptional profile of colonic organoids from patients with high blood pressure by minocycline.
Am Heart J Plus
; 362023 Dec.
Article
em En
| MEDLINE
| ID: mdl-38222308
ABSTRACT
Minocycline, an anti-inflammatory antibiotic drug, rebalances impaired gut microbiota, attenuates neuroinflammation and lowers high blood pressure in animal models of hypertension and in hypertensive patients. Our objective in this study was to investigate if antihypertensive effects of minocycline involve the expression of gut epithelial genes relevant to blood pressure homeostasis using human colonic 3-dimensional organoid culture and high-throughput RNA sequencing. The data demonstrates that minocycline could restore impaired expression of functional genes linked to viral and bacterial immunity, inflammation, protein trafficking and autophagy in human hypertensive organoids.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Am Heart J Plus
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China