Signalling of Adrenoceptors: Canonical Pathways and New Paradigms.
Handb Exp Pharmacol
; 2024 Jan 17.
Article
em En
| MEDLINE
| ID: mdl-38227198
ABSTRACT
The concept of G protein-coupled receptors initially arose from studies of the ß-adrenoceptor, adenylyl cyclase, and cAMP signalling pathway. Since then both canonical G protein-coupled receptor signalling pathways and emerging paradigms in receptor signalling have been defined by experiments focused on adrenoceptors. Here, we discuss the evidence for G protein coupling specificity of the nine adrenoceptor subtypes. We summarise the ability of each of the adrenoceptors to activate proximal signalling mediators including cAMP, calcium, mitogen-activated protein kinases, and protein kinase C pathways. Finally, we highlight the importance of precise spatial and temporal control of adrenoceptor signalling that is controlled by the localisation of receptors at intracellular membranes and in larger protein complexes.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Handb Exp Pharmacol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Austrália