Impact of initiation of SGLT2 inhibitor treatment on the development of arrhythmias in patients with implantable cardiac devices.
Rev Esp Cardiol (Engl Ed)
; 77(6): 481-489, 2024 Jun.
Article
em En, Es
| MEDLINE
| ID: mdl-38246269
ABSTRACT
INTRODUCTION AND OBJECTIVES:
Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) have been associated with improved prognosis in patients with heart failure, but their impact on atrial arrhythmic (AA) and ventricular arrhythmic (VA) events is not fully understood.METHODS:
This multicenter retrospective study included patients with implantable cardioverter-defibrillators who initiated treatment with SGLT2i. AA and VA events were compared in 2 time periods for each patient 1 year before and 1 year after starting SGLT2i.RESULTS:
The study included 195 patients (66.8 [61.3-73.1] years, 18.5% women). In the post-SGLT2i period, there was a reduction in the percentage of patients with any VA (pre 52.3% vs post 30.3%; P<.001) and clinically relevant VA (excluding nonsustained ventricular tachycardia) (pre 21.5% vs post 8.7%; P<.001). There was also a decrease in the number of episodes per patient/y of nonsustained ventricular tachycardia (pre 2 (1-5) vs post 1 (0-2); P<.001) and sustained ventricular tachycardia (pre 1 (1-3) vs post 0 (0-2); P=0.046). However, no differences were observed in the prevalence of AA (24.7% vs 18.8%; P=.117) or the burden of atrial fibrillation (pre 0% (0-0.1) vs post 0% (0-0); P=.097).CONCLUSIONS:
Initiation of SGLT2i treatment was associated with a decrease in the percentage of patients with relevant VA but this effect was not observed for AA.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
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Desfibriladores Implantáveis
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Inibidores do Transportador 2 de Sódio-Glicose
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
/
Es
Revista:
Rev Esp Cardiol (Engl Ed)
Ano de publicação:
2024
Tipo de documento:
Article