Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin.
Sci Adv
; 10(4): eadj3880, 2024 Jan 26.
Article
em En
| MEDLINE
| ID: mdl-38266092
ABSTRACT
Early-life stress experiences can produce lasting impacts on organismal adaptation and fitness. How transient stress elicits memory-like physiological effects is largely unknown. Here, we show that early-life thermal stress strongly up-regulates tsp-1, a gene encoding the conserved transmembrane tetraspanin in C. elegans. TSP-1 forms prominent multimers and stable web-like structures critical for membrane barrier functions in adults and during aging. Increased TSP-1 abundance persists even after transient early-life heat stress. Such regulation requires CBP-1, a histone acetyltransferase that facilitates initial tsp-1 transcription. Tetraspanin webs form regular membrane structures and mediate resilience-promoting effects of early-life thermal stress. Gain-of-function TSP-1 confers marked C. elegans longevity extension and thermal resilience in human cells. Together, our results reveal a cellular mechanism by which early-life thermal stress produces long-lasting memory-like impact on organismal resilience and longevity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Caenorhabditis elegans
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Resiliência Psicológica
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Experiências Adversas da Infância
Limite:
Adult
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Animals
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Humans
Idioma:
En
Revista:
Sci Adv
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos