Your browser doesn't support javascript.
loading
Functional diversification of cell signaling by GPCR localization.
Klauer, Matthew J; Willette, Blair K A; Tsvetanova, Nikoleta G.
Afiliação
  • Klauer MJ; Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA.
  • Willette BKA; Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA.
  • Tsvetanova NG; Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA. Electronic address: nikoleta.tsvetanova@duke.edu.
J Biol Chem ; 300(3): 105668, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38272232
ABSTRACT
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and a critical class of regulators of mammalian physiology. Also known as seven transmembrane receptors (7TMs), GPCRs are ubiquitously expressed and versatile, detecting a diverse set of endogenous stimuli, including odorants, neurotransmitters, hormones, peptides, and lipids. Accordingly, GPCRs have emerged as the largest class of drug targets, accounting for upward of 30% of all prescription drugs. The view that ligand-induced GPCR responses originate exclusively from the cell surface has evolved to reflect accumulating evidence that receptors can elicit additional waves of signaling from intracellular compartments. These events in turn shape unique cellular and physiological outcomes. Here, we discuss our current understanding of the roles and regulation of compartmentalized GPCR signaling.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptores Acoplados a Proteínas G Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptores Acoplados a Proteínas G Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos