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Variant ALK-fusion positive anaplastic large cell lymphoma (ALCL): A population-based paediatric study of the NHL-BFM study group.
Luedersen, Jette; Stadt, Udo Zur; Richter, Julia; Oschlies, Ilske; Klapper, Wolfram; Rosenwald, Andreas; Kalinova, Marketa; Simonitsch-Klupp, Ingrid; Siebert, Reiner; Zimmermann, Martin; Qi, Minyue; Nakel, Jacqueline; Scheinemann, Katrin; Knörr, Fabian; Attarbaschi, Andishe; Kabickova, Edita; Woessmann, Wilhelm; Damm-Welk, Christine.
Afiliação
  • Luedersen J; Paediatric Haematology and Oncology and NHL-BFM Study Centre, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  • Stadt UZ; Paediatric Haematology and Oncology and CoALL Study Centre, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  • Richter J; Department of Pathology, Haematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Oschlies I; Department of Pathology, Haematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Klapper W; Department of Pathology, Haematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Rosenwald A; Department of Pathology, University of Wuerzburg, Wuerzburg, Germany.
  • Kalinova M; Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University Prague and University Hospital in Motol, Prague, Czech Republic.
  • Simonitsch-Klupp I; Department of Pathology, 3rd Faculty of Medicine, Charles University Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
  • Siebert R; Department of Pathology, Medical University of Vienna, Vienna, Austria.
  • Zimmermann M; Institute of Human Genetics, Ulm University & Ulm University Medical Centre, Ulm, Germany.
  • Qi M; Department of Paediatric Haematology and Oncology, Hannover Medical School, and NHL-BFM Study Centre, Hannover, Germany.
  • Nakel J; Bioinformatics Core, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  • Scheinemann K; Leibniz Institute of Virology (LIV), Hamburg, Germany.
  • Knörr F; Division of Paediatric Haematology/Oncology, Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland.
  • Attarbaschi A; Faculty of Health Science and Medicine, University of Lucerne, Lucerne, Switzerland.
  • Kabickova E; Department of Paediatrics, McMaster Children's Hospital and McMaster University, Hamilton, Ontario, Canada.
  • Woessmann W; Paediatric Haematology and Oncology and NHL-BFM Study Centre, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  • Damm-Welk C; Mildred Scheel Cancer Career Centre HaTriCS4, University Medical Centre Hamburg- Eppendorf, Hamburg, Germany.
Br J Haematol ; 204(5): 1894-1898, 2024 May.
Article em En | MEDLINE | ID: mdl-38279625
ABSTRACT
Frequency, distribution and prognostic meaning of ALK-partner genes other than NPM1 in ALK-positive anaplastic large-cell lymphoma (ALCL) are unknown. Forty-nine of 316 ALCL diagnosed in the NHL-BFM study group showed no nuclear ALK expression suggestive of a variant ALK-partner; 41 were analysed by genomic capture high-throughput sequencing or specific RT-PCRs. NPM1ALK was detected in 13 cases. Among the 28 patients with a non-NPM1ALK-fusion partner, ATIC (n = 8; 29%) and TPM3 (n = 9; 32%) were the most common. Five of eight patients with ATICALK-positive ALCL relapsed, none of nine with TPM3ALK. Variant ALK-partners are rare and potentially associated with different prognoses.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma Anaplásico de Células Grandes / Quinase do Linfoma Anaplásico / Nucleofosmina Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Br J Haematol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma Anaplásico de Células Grandes / Quinase do Linfoma Anaplásico / Nucleofosmina Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Br J Haematol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha