A Review on Synthetic Thiazole Derivatives as an Antimalarial Agent.
Curr Drug Discov Technol
; 21(5): e240124226141, 2024.
Article
em En
| MEDLINE
| ID: mdl-38279721
ABSTRACT
BACKGROUND:
Thiazole is a widely studied core structure in heterocyclic chemistry and has proven to be a valuable scaffold in medicinal chemistry. The presence of thiazole in both naturally occurring and synthetic pharmacologically active compounds demonstrates the adaptability of these derivatives.METHODS:
The current study attempted to review and compile the contributions of numerous researchers over the last 20 years to the medicinal importance of these scaffolds, with a primary focus on antimalarial activity. The review is based on an extensive search of PubMed, Google Scholar, Elsevier, and other renowned journal sites for a thorough literature survey involving various research and review articles.RESULTS:
A comprehensive review of the antimalarial activity of the thiazole scaffold revealed potential therapeutic targets in Plasmodium species. Furthermore, the correlation of structure-activity-relationship (SAR) studies from various articles suggests that the thiazole ring has therapeutic potential.CONCLUSION:
This article intends to point researchers in the right direction for developing potential thiazole-based compounds as antimalarial agents in the future.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Antimaláricos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Drug Discov Technol
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia