Osteopontin in cancer.
Adv Clin Chem
; 118: 87-110, 2024.
Article
em En
| MEDLINE
| ID: mdl-38280808
ABSTRACT
Osteopontin (OPN) is a heavily post-translationally modified protein with a molecular weight of 44-70 kDa, depending on the degree of glycosylation. OPN is involved in various biological processes, including bone remodeling, immune response, cell adhesion, migration, and survival. It is essential for controlling osteoclast and osteoblast activity for maintaining bone mass and bone strength. Additionally, OPN has been linked to cardiovascular, inflammatory illnesses, as well as the onset and progression of cancer. OPN is a multifunctional protein that can interact with a variety of cell surface receptors, such as integrins, CD44, the urokinase-type plasminogen activator receptor (uPAR), as well as extracellular matrix (ECM) components (e.g. collagen and hydroxyapatite). These interactions contribute to its wide range of biological functions in general and has significant implications for bone biology, immunology and cancer, specifically. In this chapter, we summarize the structure of OPN with a focus on its molecular mechanisms of action in various cancers.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Osteopontina
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Adv Clin Chem
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia