Leukocyte Telomere Length and Cardiac Structure and Function: A Mendelian Randomization Study.
J Am Heart Assoc
; 13(3): e032708, 2024 Feb 06.
Article
em En
| MEDLINE
| ID: mdl-38293941
ABSTRACT
BACKGROUND:
Existing research demonstrates the association of shorter leukocyte telomere length with increased risk of age-related health outcomes including cardiovascular diseases. However, the direct causality of these relationships has not been definitively established. Cardiovascular aging at an organ level may be captured using image-derived phenotypes of cardiac anatomy and function. METHODS ANDRESULTS:
In the current study, we use 2-sample Mendelian randomization to assess the causal link between leukocyte telomere length and 54 cardiac magnetic resonance imaging measures representing structure and function across the 4 cardiac chambers. Genetically predicted shorter leukocyte telomere length was causally linked to smaller ventricular cavity sizes including left ventricular end-systolic volume, left ventricular end-diastolic volume, lower left ventricular mass, and pulmonary artery. The association with left ventricular mass (ß =0.217, Pfalse discovery rate=0.016) remained significant after multiple testing adjustment, whereas other associations were attenuated.CONCLUSIONS:
Our findings support a causal role for shorter leukocyte telomere length and faster cardiac aging, with the most prominent relationship with left ventricular mass.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Análise da Randomização Mendeliana
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Coração
Tipo de estudo:
Clinical_trials
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Prognostic_studies
Idioma:
En
Revista:
J Am Heart Assoc
Ano de publicação:
2024
Tipo de documento:
Article