Your browser doesn't support javascript.
loading
Alzheimer DataLENS: An Open Data Analytics Portal for Alzheimer's Disease Research.
Noori, Ayush; Jayakumar, Rojashree; Moturi, Vaishnavi; Li, Zhaozhi; Liu, Rongxin; Serrano-Pozo, Alberto; Hyman, Bradley T; Das, Sudeshna.
Afiliação
  • Noori A; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
  • Jayakumar R; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
  • Moturi V; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
  • Li Z; Department of Computational Biology, Cornell University, Ithaca, NY, USA.
  • Liu R; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
  • Serrano-Pozo A; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
  • Hyman BT; Harvard Medical School, Boston, MA, USA.
  • Das S; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
J Alzheimers Dis ; 99(s2): S397-S407, 2024.
Article em En | MEDLINE | ID: mdl-38306039
ABSTRACT

Background:

Recent Alzheimer's disease (AD) discoveries are increasingly based on studies from a variety of omics technologies on large cohorts. Currently, there is no easily accessible resource for neuroscientists to browse, query, and visualize these complex datasets in a harmonized manner.

Objective:

Create an online portal of public omics datasets for AD research.

Methods:

We developed Alzheimer DataLENS, a web-based portal, using the R Shiny platform to query and visualize publicly available transcriptomics and genetics studies of AD on human cohorts. To ensure consistent representation of AD findings, all datasets were processed through a uniform bioinformatics pipeline.

Results:

Alzheimer DataLENS currently houses 2 single-nucleus RNA sequencing datasets, over 30 bulk RNA sequencing datasets from 19 brain regions and 3 cohorts, and 2 genome-wide association studies (GWAS). Available visualizations for single-nucleus data include bubble plots, heatmaps, and UMAP plots; for bulk expression data include box plots and heatmaps; for pathways include protein-protein interaction network plots; and for GWAS results include Manhattan plots. Alzheimer DataLENS also links to two other knowledge resources the AD Progression Atlas and the Astrocyte Atlas.

Conclusions:

Alzheimer DataLENS is a valuable resource for investigators to quickly and systematically explore omics datasets and is freely accessible at https//alzdatalens.partners.org.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Humans Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Humans Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos