Rh(III)-Catalyzed C7-Alkylation of Isatogens with Malonic Acid Diazoesters.
J Org Chem
; 89(5): 2984-2995, 2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38334453
ABSTRACT
Rh(III)-catalyzed C7-alkylation of isatogens (indolin-3-one N-oxides) with malonic acid diazoesters has been developed. This strategy utilizes oxygen anion on the N-oxide group of isatogens as a directing group and successfully achieves the synthesis of a series of C7-alkylated isatogens with moderate to good yields (48-86% yields). Moreover, the N-oxides of isatogens can not only serve as the simple directing group for C7-H bond cleavage but also be deoxidized for easy removal.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2024
Tipo de documento:
Article