Liquid Biopsy Based on Cell-Free DNA and RNA.
Annu Rev Biomed Eng
; 26(1): 169-195, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38346275
ABSTRACT
This review delves into the rapidly evolving landscape of liquid biopsy technologies based on cell-free DNA (cfDNA) and cell-free RNA (cfRNA) and their increasingly prominent role in precision medicine. With the advent of high-throughput DNA sequencing, the use of cfDNA and cfRNA has revolutionized noninvasive clinical testing. Here, we explore the physical characteristics of cfDNA and cfRNA, present an overview of the essential engineering tools used by the field, and highlight clinical applications, including noninvasive prenatal testing, cancer testing, organ transplantation surveillance, and infectious disease testing. Finally, we discuss emerging technologies and the broadening scope of liquid biopsies to new areas of diagnostic medicine.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA
/
Sequenciamento de Nucleotídeos em Larga Escala
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Ácidos Nucleicos Livres
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Annu Rev Biomed Eng
Assunto da revista:
ENGENHARIA BIOMEDICA
Ano de publicação:
2024
Tipo de documento:
Article