Plasma SOMAmer proteomics of postoperative delirium.
Brain Behav
; 14(2): e3422, 2024 02.
Article
em En
| MEDLINE
| ID: mdl-38346717
ABSTRACT
BACKGROUND:
Postoperative delirium is prevalent in older adults and has been shown to increase the risk of long-term cognitive decline. Plasma biomarkers to identify the risk for postoperative delirium and the risk of Alzheimer's disease and related dementias are needed.METHODS:
This biomarker discovery case-control study aimed to identify plasma biomarkers associated with postoperative delirium. Patients aged ≥65 years undergoing major elective noncardiac surgery were recruited. The preoperative plasma proteome was interrogated with SOMAmer-based technology targeting 1433 biomarkers.RESULTS:
In 40 patients (20 with vs. 20 without postoperative delirium), a preoperative panel of 12 biomarkers discriminated patients with postoperative delirium with an accuracy of 97.5%. The final model of five biomarkers delivered a leave-one-out cross-validation accuracy of 80%. Represented biological pathways included lysosomal and immune response functions.CONCLUSION:
In older patients who have undergone major surgery, plasma SOMAmer proteomics may provide a relatively non-invasive benchmark to identify biomarkers associated with postoperative delirium.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Delírio
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Delírio do Despertar
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Humans
Idioma:
En
Revista:
Brain Behav
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos