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Exposure to heavy metal elements may significantly increase serum prostate-specific antigen levels with overdosed dietary zinc.
Fang, Yinyi; Chen, Chi; Chen, Xiaoyue; Song, Jukun; Feng, Shuangshuang; Li, Zhuang; Li, Zhengnan; Xiong, Yuliang; Zhang, Qinyi; Su, Hao; Liu, Heng; Zhu, Guohua; Hu, Bin; Wang, Wei; Liu, Zhangcheng; Jiao, Ke; Zhang, Chang; Zhang, Fan; Jiang, Kehua; He, Jun; Sun, Zhaolin; Yuan, Dongbo; Chen, Weiming; Zhu, Jianguo.
Afiliação
  • Fang Y; Guizhou University Medical College, Guiyang city, Guizhou Province 550025, China; People's Hospital Affiliated to Guizhou University, Guiyang city, Guizhou Province, China.
  • Chen C; Department of Immunology and Microbiology, Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou Province 550001, China.
  • Chen X; Guizhou University Medical College, Guiyang city, Guizhou Province 550025, China.
  • Song J; Guizhou University Medical College, Guiyang city, Guizhou Province 550025, China; People's Hospital Affiliated to Guizhou University, Guiyang city, Guizhou Province, China.
  • Feng S; Guizhou University Medical College, Guiyang city, Guizhou Province 550025, China.
  • Li Z; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; Guizhou Medical University, Guiyang city, Guizhou Province, China.
  • Li Z; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; Zunyi Medcical University, Zunyi City, Guizhou Province, China.
  • Xiong Y; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; Guizhou Medical University, Guiyang city, Guizhou Province, China.
  • Zhang Q; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; Zunyi Medcical University, Zunyi City, Guizhou Province, China.
  • Su H; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; Zunyi Medcical University, Zunyi City, Guizhou Province, China.
  • Liu H; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; Zunyi Medcical University, Zunyi City, Guizhou Province, China.
  • Zhu G; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; Guizhou Medical University, Guiyang city, Guizhou Province, China.
  • Hu B; Zunyi Medcical University, Zunyi City, Guizhou Province, China.
  • Wang W; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; Guizhou Medical University, Guiyang city, Guizhou Province, China.
  • Liu Z; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; Zunyi Medcical University, Zunyi City, Guizhou Province, China.
  • Jiao K; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; Guizhou Medical University, Guiyang city, Guizhou Province, China.
  • Zhang C; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China.
  • Zhang F; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; Guizhou Medical University, Guiyang city, Guizhou Province, China.
  • Jiang K; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China.
  • He J; Department of Reproductive Medicine, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China.
  • Sun Z; Guizhou University Medical College, Guiyang city, Guizhou Province 550025, China; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; People's Hospital Affiliated to Guizhou University, Guiyang city, Guizhou Province, China.
  • Yuan D; Guizhou University Medical College, Guiyang city, Guizhou Province 550025, China; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; People's Hospital Affiliated to Guizhou University, Guiyang city, Guizhou Province, China. Electronic address: yab
  • Chen W; Guizhou University Medical College, Guiyang city, Guizhou Province 550025, China; People's Hospital Affiliated to Guizhou University, Guiyang city, Guizhou Province, China; Department of Reproductive Medicine, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China. Electr
  • Zhu J; Guizhou University Medical College, Guiyang city, Guizhou Province 550025, China; Urology Department, Guizhou Provincial People's Hospital, Guiyang city, Guizhou Province 550002, China; People's Hospital Affiliated to Guizhou University, Guiyang city, Guizhou Province, China. Electronic address: doc
Ecotoxicol Environ Saf ; 272: 116080, 2024 Mar 01.
Article em En | MEDLINE | ID: mdl-38350215
ABSTRACT

BACKGROUND:

Serum prostate-specific antigen (PSA) is a primary metric for diagnosis and prognosis of prostate cancer (PCa). Exposure to heavy metals, such as lead, cadmium, mercury, and zinc can impact PSA levels in PCa patients. However, it is unclear whether this effect also occurs in men without PCa, which may lead to the overdiagnosis of PCa.

METHOD:

Data on a total of 5089 American men who had never been diagnosed with PCa were obtained from the National Health and Nutrition Examination Survey performed from 2003-2010. The relationship between serum PSA levels (dependent variable) and concentrations of lead (µmol/L), cadmium (nmol/L), and mercury (µmol/L) were investigated with dietary zinc intake being used as a potential modifier or covariate in a weighted linear regression model and a generalized additive model. A series of bootstrapping analyses were performed to evaluate sensitivity and specificity using these models.

RESULTS:

Regression analyses suggested that, in general, lead, cadmium, or mercury did not show an association with PSA levels, which was consistent with the results of the bootstrapping analyses. However, in a subgroup of participants with a high level of dietary zinc intake (≥14.12 mg/day), a significant positive association between cadmium and serum PSA was identified (1.06, 95% CI, P = 0.0268, P for interaction=0.0249).

CONCLUSIONS:

With high-level zinc intake, serum PSA levels may rise in PCa-free men as the exposure to cadmium increases, leading to a potential risk of an overdiagnosis of PCa and unnecessary treatment. Therefore, environmental variables should be factored in the current diagnostic model for PCa that is solely based on PSA measurements. Different criteria for PSA screening are necessary based on geographical variables. Further investigations are needed to uncover the biological and biochemical relationship between zinc, cadmium, and serum PSA levels to more precisely diagnose PCa.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metais Pesados / Mercúrio Tipo de estudo: Prognostic_studies Limite: Humans / Male País/Região como assunto: America do norte Idioma: En Revista: Ecotoxicol Environ Saf Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metais Pesados / Mercúrio Tipo de estudo: Prognostic_studies Limite: Humans / Male País/Região como assunto: America do norte Idioma: En Revista: Ecotoxicol Environ Saf Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China