Efficacy and safety of respiratory syncytial virus vaccination during pregnancy to prevent lower respiratory tract illness in newborns and infants: a systematic review and meta-analysis of randomized controlled trials.
Front Pediatr
; 11: 1260740, 2023.
Article
em En
| MEDLINE
| ID: mdl-38357264
ABSTRACT
To evaluate the effectiveness and safety of respiratory syncytial virus (RSV) vaccination during pregnancy in preventing lower respiratory tract infection (LRTI) in infants and neonates, we conducted a systematic search of randomized controlled trials (RCTs) in five databases (PubMed, Embase and Cochrane Library, Web of Science, Cochrane Center Register of Controlled trial) until 1 May 2023. We performed a meta-analysis of the eligible trials using RevMan5.4.1 software. Our analysis included six articles and five RCTs. The meta-analysis revealed significant differences in the incidences of LRTI [risk ratio (RR) 0.64; 95% confidence interval (CI) 0.43, 0.96; p = 0.03)] and severe LRTI (RR 0.37; 95% CI 0.18, 0.79; p = 0.01) between the vaccine group and the placebo group for newborns and infants. These differences were observed at 90, 120, and 150 days after birth (p = 0.003, p = 0.05, p = 0.02, p = 0.03, p = 0.009, p = 0.05). At 180 days after birth, there was a significant difference observed in the incidence of LRTI between the two groups (RR 0.43; 95% CI 0.21, 0.90; p = 0.02). The safety results showed a significant difference in the incidence of common adverse events between the two groups (RR 1.08; 95% CI 1.04, 1.12; p < 0.0001). However, there was no significant difference observed in the incidence of serious adverse events (RR 1.05; 95% CI 0.97, 1.15; p = 0.23), common and serious adverse events (RR 1.02; 95% CI 0.96, 1.10; p = 0.23), or common and serious adverse events among pregnant women and newborns and infants (RR 0.98; 95% CI 0.93, 1.04; p = 0.52). In conclusion, maternal RSV vaccination is an effective and safe immunization strategy for preventing LRTI in postpartum infants, with greater efficacy observed within the first 150 days after birth.
Texto completo:
1
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
/
Systematic_reviews
Idioma:
En
Revista:
Front Pediatr
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China