Does Gut Microbiome have an Effect on Wilson's Disease Phenotype?
Curr Med Chem
; 2024 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-38362687
ABSTRACT
Wilson's Disease (WD), a genetic metabolic disorder, is characterized by the accumulation of copper in the liver and brain, resulting in a range of clinical symptoms. The clinical manifestations of WD vary widely. The present study introduces the distinctive features of intestinal microbiota in Chinese patients with WD, presenting diverse clinical symptoms. It shows a reduction in the diversity of gut microbiota among patients with hepatic symptoms associated with WD, particularly in the genus responsible for SCFAs production. It demonstrates an increase in the Haemophilus microorganism. This study may offer novel insights for further investigation into the mechanisms underlying the occurrence, development, and treatment of WD subtypes.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
Curr Med Chem
/
Curr. med. chem
/
Current medicinal chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China