MYBBP1A is required for efficient replication and gene expression of herpes simplex virus 1.
Microbiol Immunol
; 68(4): 148-154, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38402407
ABSTRACT
More than 100 different herpes simplex virus 1 (HSV-1) genes belong to three major classes, and their expression is coordinately regulated and sequentially ordered in a cascade. This complex HSV-1 gene expression is thought to be regulated by various viral and host cellular proteins. A host cellular protein, Myb-binding protein 1A (MYBBP1A), has been reported to be associated with HSV-1 viral genomes in conjunction with viral and cellular proteins critical for DNA replication, repair, and transcription within infected cells. However, the role(s) of MYBBP1A in HSV-1 infections remains unclear. In this study, we examined the effects of MYBBP1A depletion on HSV-1 infection and found that MYBBP1A depletion significantly reduced HSV-1 replication, as well as the accumulation of several viral proteins. These results suggest that MYBBP1A is an important host cellular factor that contributes to HSV-1 replication, plausibly by promoting viral gene expression.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas de Ligação a RNA
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Herpesvirus Humano 1
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Proteínas de Ligação a DNA
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Herpes Simples
Limite:
Humans
Idioma:
En
Revista:
Microbiol Immunol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão