Injectable polyoxazoline grafted hyaluronic acid thermoresponsive hydrogels for biomedical applications.
J Mater Chem B
; 12(11): 2807-2817, 2024 Mar 13.
Article
em En
| MEDLINE
| ID: mdl-38404247
ABSTRACT
Injectable thermosensitive hydrogels based on hyaluronic acid (HA) grafted with lower critical solution temperature (LCST) polyoxazoline (copolymers of poly(isopropyl-co-butyl oxazoline)) or P(iPrOx-co-BuOx) have been elaborated with tunable solution/gel temperature transitions and gel state elastic modulus. A suitable HA-g-P(iPrOx-co-BuOx-67/33)-0.10 sample with an iPrOx/BuOx ratio of 67/33, a polymerization degree (DP) of 25, a substitution degree (DS) of 10%, and displaying thermally induced gelling character with elastic (G') and viscous (G'') moduli crossover points at 25 °C and a G' at 37 °C around 80 Pa has been chosen for medical application. Hydrogels obtained with HA-g-P(iPrOx-co-BuOx-67/33)-0.10 exhibited high stability at 37 °C and excellent injectability properties with full and quick reversibility. The incorporation of a secondary network (HA), until 35 wt%, into the thermosensitive hydrogel also demonstrated very good stability and injectability.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hidrogéis
/
Ácido Hialurônico
Idioma:
En
Revista:
J Mater Chem B
/
J. mater. chem. B (Online)
/
Journal of materials chemistry. B (Online)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
França