Safety and effcacy of remimazolam tosilate for sedation during combined spinal-epidural anesthesia for orthopedic procedures: a randomized controlled trial.
BMC Anesthesiol
; 24(1): 75, 2024 Feb 26.
Article
em En
| MEDLINE
| ID: mdl-38408901
ABSTRACT
OBJECTIVE:
The objective of this study was to assess the efficacy and safety of Remimazolam in the context of combined spinal-epidural anesthesia for sedation during orthopedic surgery.METHODS:
This randomized controlled trial enrolled patients scheduled for orthopedic surgery under combined spinal-epidural anesthesia (N = 80), who were randomly allocated to receive either dexmedetomidine (Group-D) or remimazolam (Group-R). The target sedation range aimed for a Ramsay score of 2-5 or a BIS value of 60-80 to evaluate the effectiveness and safety of remimazolam during sedation.RESULTS:
The time taken to achieve the desired level of sedation was significantly shorter in the remimazolam group compared to the dexmedetomidine group (3.69 ± 0.75 vs. 9.59 ± 1.03; P < 0.0001). Patients in the remimazolam group exhibited quicker recovery, fewer intraoperative adverse events, more consistent vital signs, and greater satisfaction at various time points throughout the surgery.CONCLUSION:
This preliminary study demonstrates that remimazolam tosilate serves as a safe and effective sedative for orthopedic surgery performed under combined spinal-epidural anesthesia, in comparison with dexmedetomidine.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzenossulfonatos
/
Benzodiazepinas
/
Hipnóticos e Sedativos
Limite:
Humans
Idioma:
En
Revista:
BMC Anesthesiol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China