Shaping epithelial lumina under pressure.
Biochem Soc Trans
; 2024 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-38415294
ABSTRACT
The formation of fluid- or gas-filled lumina surrounded by epithelial cells pervades development and disease. We review the balance between lumen pressure and mechanical forces from the surrounding cells that governs lumen formation. We illustrate the mechanical side of this balance in several examples of increasing complexity, and discuss how recent work is beginning to elucidate how nonlinear and active mechanics and anisotropic biomechanical structures must conspire to overcome the isotropy of pressure to form complex, non-spherical lumina.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
Biochem Soc Trans
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Alemanha