Targeting neutrophil extracellular traps: A novel strategy in hematologic malignancies.
Biomed Pharmacother
; 173: 116334, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38422658
ABSTRACT
Neutrophil extracellular traps (NETs) have emerged as a critical factor in malignant hematologic disease pathogenesis. These structures, comprising DNA, histones, and cytoplasmic proteins, were initially recognized for their role in immune defense against microbial threats. Growing evidence suggests that NETs contribute to malignant cell progression and dissemination, representing a double-edged sword. However, there is a paucity of reports on its involvement in hematological disorders. A comprehensive understanding of the intricate relationship between malignant cells and NETs is necessary to explore effective therapeutic strategies. This review highlights NET formation and mechanisms underlying disease pathogenesis. Moreover, we discuss recent advancements in targeted inhibitor development for selective NET disruption, empowering precise design and efficacious therapeutic interventions for malignant hematologic diseases.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hematológicas
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Armadilhas Extracelulares
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Doenças Hematológicas
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Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Biomed Pharmacother
Ano de publicação:
2024
Tipo de documento:
Article