Characteristics and literature review of ETV6::ABL1 fusion gene-positive acute myeloid leukemia.
Int J Hematol
; 119(5): 564-572, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38441775
ABSTRACT
OBJECTIVE:
To describe the features of ETV6ABL1 AML as well as the clinical treatment and outcomes.METHODS:
Clinical data were collected from three patients diagnosed with ETV6ABL1 AML at Hebei Yanda Lu Daopei Hospital and Beijing Lu Daopei Hospital. Their clinical and laboratory features were analyzed, and the treatment process and outcomes were described. Ten reported cases of ETV6ABL1 AML from the literature were also included for analysis.RESULTS:
The median age of the patients was 34 years, and 2 patients were male. No patient had a history of blood disorders before diagnosis. After relapse, they were referred to our hospital, where the ETV6ABL1 gene was detected. Unfortunately, Patient 1 died rapidly after leukemia relapse due to severe infection. Patients 2 and 3 received salvage therapy with a dasatinib-containing regimen, followed by allo-HSCT, and are currently alive and disease-free.CONCLUSION:
ETV6ABL1 is a rare but recurrent genetic aberration in AML, and the combined use of fluorescence in situ hybridization and PCR can better identify this fusion gene. Patients carrying ETV6ABL1 have a high relapse rate and a poor prognosis. TKIs are a reasonable treatment option for this group, and allo-HSCT may be curative.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
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Leucemia Mieloide Aguda
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Proteínas de Fusão Oncogênica
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Proteínas Proto-Oncogênicas c-ets
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Variante 6 da Proteína do Fator de Translocação ETS
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Int J Hematol
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China