Congenital adrenal hyperplasia complicated by gonadotropin-dependent precocious puberty.
BMJ Case Rep
; 17(3)2024 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-38442976
ABSTRACT
Precocious puberty, characterised by the early appearance of secondary sexual characteristics, poses challenges in diagnosis and management. Here, we describe a case of precocious puberty diagnosed in a boy in middle childhood, who presented with progressive phallus enlargement, pubic hair development and increased aggressive behaviour. Hormonal evaluation confirmed the diagnosis of congenital adrenal hyperplasia (CAH), complicated by gonadotropin-dependent precocious puberty. The case highlights the importance of assessment of testicular volume in a patient presenting with precocious puberty. Symmetrical testicular enlargement in a patient with CAH suggests premature activation of the hypothalamic-pituitary-gonadal axis. The patient received glucocorticoid therapy to suppress androgen production related to CAH and gonadotropin-releasing hormone analogue therapy to control premature activation of the hypothalamic-pituitary-gonadal axis. Follow-up visits showed regression of secondary sexual characteristics and improved growth velocity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Puberdade Precoce
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Hiperplasia Suprarrenal Congênita
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Parede Abdominal
Limite:
Child
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Humans
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Male
Idioma:
En
Revista:
BMJ Case Rep
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia