Decreased oxytocin levels related to social cognition impairment in borderline personality disorder.
Acta Psychiatr Scand
; 149(6): 458-466, 2024 06.
Article
em En
| MEDLINE
| ID: mdl-38477064
ABSTRACT
INTRODUCTION:
Dysfunctions in the oxytocin system have been reported in patients with borderline personality disorder (BPD). Deficits could be related to interpersonal hypersensitivity, which has been previously associated with failures in social cognition (SC) in this disorder, especially in Theory of Mind (ToM) skills. The aim of this work is to study the links between the oxytocin system and SC impairments in patients with BPD.METHOD:
Plasma oxytocin levels (OXT) and protein expression of oxytocin receptors in blood mononuclear cells (OXTR) were examined in 33 patients with a diagnosis of BPD (age M 28.85, DT = 8.83). Social cognition was assessed using the Movie for the Assessment of Social Cognition (MASC). Statistical associations between biochemical factors and different response errors in MASC were analyzed through generalized linear regression controlling for relevant clinical factors.RESULTS:
Generalized linear regression showed a significant relationship between lower OXTR and overmentalization in BPD patients (OR = 0.90).CONCLUSIONS:
This work supports the relationship between alterations in the oxytocin system and ToM impairments observed in BPD patients, enhancing the search for endophenotypes related to the phenotypic features of the disorder to improve current clinical knowledge and address more specific therapeutic targets.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtorno da Personalidade Borderline
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Ocitocina
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Receptores de Ocitocina
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Teoria da Mente
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Cognição Social
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Acta Psychiatr Scand
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha