IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging.

Finlay, Conor M; Allen, Judith E

Finlay, Conor M; Allen, Judith E.

Afiliação

Finlay CM; Trinity Translational Medicine Institute, School of Medicine, Trinity College Dublin, Dublin, Ireland. Electronic address: cofinlay@tcd.ie.
Allen JE; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute for Immunology & Infection, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK. Electronic address: judi.allen@manchester.ac.uk.

Immunity ; 57(3): 403-406, 2024 Mar 12.

Article em En | MEDLINE | ID: mdl-38479355

ABSTRACT

ABSTRACT

Macrophages activated via the IL-4 receptor possess non-immune functions that support tissue homeostasis, but their specific role in aging is unknown. In this issue of Immunity, Zhou et al. show that IL-4 extends lifespan by inducing DNA repair pathways that protect macrophages from cellular senescence.

Assuntos

Interleucina-4; Macrófagos; Interleucina-4/metabolismo; Senescência Celular; Longevidade

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interleucina-4 / Macrófagos Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2024 Tipo de documento: Article

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