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Choroid plexus volume differentiates MS from its mimics.
Levit, Elle; Ren, Zheng; Gonzenbach, Virgilio; Azevedo, Christina J; Calabresi, Peter A; Cree, Bruce Ac; Freeman, Leorah; Longbrake, Erin E; Oh, Jiwon; Schindler, Matthew K; Sicotte, Nancy L; Reich, Daniel S; Ontaneda, Daniel; Sati, Pascal; Cao, Quy; Shinohara, Russell T; Solomon, Andrew J.
Afiliação
  • Levit E; Department of Neurological Sciences, Larner College of Medicine, The University of Vermont, Burlington, VT, USA.
  • Ren Z; The University of Vermont Medical Center, Burlington, VT, USA.
  • Gonzenbach V; Penn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology and Informatics and Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Azevedo CJ; Penn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology and Informatics and Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Calabresi PA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Cree BA; Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Freeman L; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Longbrake EE; Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
  • Oh J; Department of Neurology, Yale University, New Haven, CT, USA.
  • Schindler MK; Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
  • Sicotte NL; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Reich DS; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Ontaneda D; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Sati P; Mellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.
  • Cao Q; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Shinohara RT; Penn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology and Informatics and Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Solomon AJ; Penn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology and Informatics and Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Mult Scler ; : 13524585241238094, 2024 Mar 13.
Article em En | MEDLINE | ID: mdl-38481081
ABSTRACT
This study aimed to determine whether choroid plexus volume (CPV) could differentiate multiple sclerosis (MS) from its mimics. A secondary analysis of two previously enrolled studies, 50 participants with MS and 64 with alternative diagnoses were included. CPV was automatically segmented from 3T magnetic resonance imaging (MRI), followed by manual review to remove misclassified tissue. Mean normalized choroid plexus volume (nCPV) to intracranial volume demonstrated relatively high specificity for MS participants in each cohort (0.80 and 0.76) with an area under the receiver-operator characteristic curve of 0.71 (95% confidence interval (CI) = 0.55-0.87) and 0.65 (95% CI = 0.52-0.77). In this preliminary study, nCPV differentiated MS from its mimics.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Mult Scler Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Mult Scler Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos