Copper Nanodrugs by Atom Transfer Radical Polymerization.
Angew Chem Int Ed Engl
; 63(20): e202402747, 2024 05 13.
Article
em En
| MEDLINE
| ID: mdl-38488767
ABSTRACT
In this study, some copper catalysts used for atom transfer radical polymerization (ATRP) were explored as efficient anti-tumor agents. The aqueous solution of copper-containing nanoparticles with uniform spheric morphology was in situ prepared through a copper-catalyzed activator generated by electron transfer (AGET) ATRP in water. Nanoparticles were then directly injected into tumor-bearing mice for antitumor chemotherapy. The copper nanodrugs had prolonged blood circulation time and enhanced accumulation at tumor sites, thus showing potent antitumor activity. This work provides a novel strategy for precise and large-scale preparation of copper nanodrugs with high antitumor activity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cobre
/
Polimerização
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Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China