Dietary Intake of (Poly)phenols and Risk of All-Cause and Cause-Specific Mortality in the Mexican Teachers' Cohort Study.
J Nutr
; 154(8): 2459-2469, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38490534
ABSTRACT
BACKGROUND:
Observational studies have reported that total (poly)phenol intake is associated with a reduction in all-cause and cardiovascular mortality, but mainly from high-income countries, where (poly)phenol intake may differ from that of low- and middle-income countries.OBJECTIVES:
Our objective was to evaluate the association between the intake of total, all classes, and subclasses of (poly)phenols and risk of all-cause and cause-specific mortality in a Mexican cohort.METHODS:
We used data from the Mexican Teachers' Cohort, which included 95,313 adult females. After a median follow-up of 11.2 y, 1725 deaths were reported, including 674 from cancer and 282 from cardiovascular diseases. (Poly)phenol intake was estimated using a validated food frequency questionnaire and the Phenol-Explorer database. Multivariable Cox models were applied to estimate the association between (poly)phenol intake and all-cause mortality and competitive risk models for cause-specific mortality.RESULTS:
Comparing extreme quartiles, total (poly)phenol intake was associated with lower risk of all-cause [hazard ratio (HR)Q4vs.Q1 0.88; 95% CI 0.76, 0.99; P-trend = 0.01] and cancer mortality (HRQ4vs.Q1 0.81; 95% CI 0.64, 0.99; P-trend = 0.02). Among (poly)phenol classes, phenolic acids, particularly hydroxycinnamic acids from coffee, showed an inverse association with all-cause (HRQ4vs.Q1 0.79; 95% CI 0.69, 0.91; P-trend = 0.002) and cancer mortality (HRQ4vs.Q1 0.75; 95% CI 0.61, 0.94; P-trend = 0.03). No associations were observed with flavonoids or with cardiovascular mortality.CONCLUSION:
Our study suggests that high (poly)phenol intake, primarily consisting of phenolic acids such as hydroxycinnamic acids, may have a protective effect on overall and cancer mortality. Null associations for flavonoid intake might be due to the potential underestimation of their intake in this population.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Dieta
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Polifenóis
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Neoplasias
Limite:
Adult
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Female
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Humans
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Middle aged
País/Região como assunto:
Mexico
Idioma:
En
Revista:
J Nutr
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha