[Recent studies about the underlying cerebral mechanism of the fearfull arousals from slow wave sleep].
Psychiatr Hung
; 39(1): 10-14, 2024.
Article
em Hu
| MEDLINE
| ID: mdl-38502014
ABSTRACT
We consider the disorders of arousal and sleep-related hypermotor epilepsy as genetic twin-conditions, one without, one with epilepsy. They share an augmented arousal-activity during NREM sleep with sleep-wake dissociations, culminating in sleep terrors and sleep-related hypermotor seizures with similar symptoms. The known mutations underlying the two spectra are different, but there are multifold population-genetic-, family- and even individual (the two conditions occurring in the same person) overlaps supporting common genetic roots. In the episodes of disorders of arousal, the anterior cingulate, anterior insular and pre-frontal cortices (shown to be involved in fear- and emotion processing) are activated within a sleeping brain. These regions overlap with the seizure-onset zones of successfully operated sleep-related hypermotor seizures, and notably, belong to the salience network being consistent with its hubs. The arousal-relatedness and the similar fearful disorientation occurring in sleep terrors and hypermotor seizures, make them alike the acute stress-responses emerging from sleep; triggered by false alarms. An acute stress-response can easily mobilize the hypothalamo-pituitary-adrenal axis (preparing fight-flight responses in wakefulness); through its direct pathways to and from the salience network. This hypothesis has never been studied.
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Base de dados:
MEDLINE
Assunto principal:
Terrores Noturnos
/
Epilepsia
/
Sono de Ondas Lentas
Limite:
Humans
Idioma:
Hu
Revista:
Psychiatr Hung
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2024
Tipo de documento:
Article