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Expeditious Synthesis of Gwanakoside A and the Chloronaphthol Glycoside Congeners.
Cheng, Yuting; Xia, Yan; Yuan, Ziqi; Li, Haotian; Wang, Jing; Wang, Yingjie; Yang, Cai-Guang; Yu, Biao.
Afiliação
  • Cheng Y; Department of Chemistry, University of Science and Technology of China, 96 JinZhai Road, Hefei, Anhui 230026, China.
  • Xia Y; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
  • Yuan Z; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
  • Li H; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
  • Wang J; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
  • Wang Y; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
  • Yang CG; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
  • Yu B; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Org Lett ; 26(12): 2425-2429, 2024 Mar 29.
Article em En | MEDLINE | ID: mdl-38506225
ABSTRACT
The synthesis of gwanakoside A, a chlorinated naphthol bis-glycoside, and its analogues was achieved through stepwise chlorination and donor-equivalent controlled regioselective phenol glycosylation with glycosyl N-phenyltrifluoroacetimidates as donors. Gwanakoside A displayed considerable inhibitory effects against various cancer cells and Staphylococcus aureus strains.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicosídeos Cardíacos / Glicosídeos Idioma: En Revista: Org Lett / Org. lett / Organic letters Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicosídeos Cardíacos / Glicosídeos Idioma: En Revista: Org Lett / Org. lett / Organic letters Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China