Concentration dependent exposure of vancomycin and teicoplanin induces vanG regulon in Staphylococcus aureus.
Indian J Med Microbiol
; 48: 100563, 2024.
Article
em En
| MEDLINE
| ID: mdl-38518847
ABSTRACT
Therapeutic options for staphylococcus infections have been raised due to the emergence of VISA and VRSA. Six isolates of Staphylococcus aureus of clinical origin which were previously confirmed to carry vanG were selected for this study. Antimicrobial susceptibility was performed by disc diffusion method. Transcriptional expression of vanG and vanSG showed down regulation against vancomycin and teicoplanin but expression was increased with increasing concentration of antibiotics. vanUG, vanRG showed up regulation against glycopeptide exposure. The present study underscored that expression of vanG and its regulatory gene operons are dependent on concentration of vancomycin and teicoplanin exposure in S.aureus.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
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Vancomicina
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Regulação Bacteriana da Expressão Gênica
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Teicoplanina
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Regulon
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Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
Indian J Med Microbiol
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article