Network switches and their role in circadian clocks.
J Biol Chem
; 300(5): 107220, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38522517
ABSTRACT
Circadian rhythms are generated by complex interactions among genes and proteins. Self-sustained â¼24 h oscillations require negative feedback loops and sufficiently strong nonlinearities that are the product of molecular and network switches. Here, we review common mechanisms to obtain switch-like behavior, including cooperativity, antagonistic enzymes, multisite phosphorylation, positive feedback, and sequestration. We discuss how network switches play a crucial role as essential components in cellular circadian clocks, serving as integral parts of transcription-translation feedback loops that form the basis of circadian rhythm generation. The design principles of network switches and circadian clocks are illustrated by representative mathematical models that include bistable systems and negative feedback loops combined with Hill functions. This work underscores the importance of negative feedback loops and network switches as essential design principles for biological oscillations, emphasizing how an understanding of theoretical concepts can provide insights into the mechanisms generating biological rhythms.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Retroalimentação Fisiológica
/
Relógios Circadianos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Biol Chem
Ano de publicação:
2024
Tipo de documento:
Article