New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239.
J Antibiot (Tokyo)
; 77(5): 265-271, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38531967
ABSTRACT
During our screening for anti-mycobacterial agents against Mycobacterium avium complex (MAC), two new polycyclic tetramate macrolactams (PTMs), named hydroxycapsimycin (1) and brokamycin (2), were isolated along with the known PTM, ikarugamycin (3), from the culture broth of marine-derived Streptomyces sp. KKMA-0239. The relative structures of 1 and 2 were elucidated by spectroscopic data analyses, including 1D and 2D NMR. Furthermore, the absolute configuration of 1 was confirmed by a single-crystal X-ray diffraction analysis. Compounds 2 and 3 exhibited moderate antimycobacterial activities against MAC, including clinically isolated drug-resistant M. avium.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
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Testes de Sensibilidade Microbiana
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Lactamas
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Antibacterianos
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão