Primary Hyperparathyroidism due to Parathyroid Adenoma in Children and Adolescents.
Endocr Pract
; 30(6): 564-568, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38556080
ABSTRACT
OBJECTIVE:
In contrast to adults, primary hyperparathyroidism (PHPT) in children and adolescents is a rare endocrine disorder.METHODS:
A retrospective review of PHPT cases between 2005 and 2022 from a single tertiary university medical center, including clinical signs and symptoms, laboratory findings, radiological evaluation, treatment, and postoperative complications.RESULTS:
Ten children (mean age at diagnosis 16.3 ± 1.3 years) were diagnosed with PHPT. All patients were in late pubertal stages without sex predominance and 8 were symptomatic. Mean calcium level was 13.6 ± 2.5 mg/dL, and mean parathyroid hormone levels were 204.8 ± 163.1 pg/mL. Parathyroid adenoma was confirmed by the postsurgical pathology results.CONCLUSIONS:
PHPT in children and adolescents is often symptomatic and more severe than adults. The main cause is single parathyroid adenoma. Associated hypercalcemic syndromes were not found. Patients were cured after surgical removal of the adenoma without significant postoperative complications and no recurrence during 10.4 ± 5.9 years follow-up.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias das Paratireoides
/
Adenoma
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Hiperparatireoidismo Primário
Limite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Endocr Pract
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article