Hypoxia-inducible factor-driven glycolytic adaptations in host-microbe interactions.
Pflugers Arch
; 476(9): 1353-1368, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38570355
ABSTRACT
Mammalian cells utilize glucose as a primary carbon source to produce energy for most cellular functions. However, the bioenergetic homeostasis of cells can be perturbed by environmental alterations, such as changes in oxygen levels which can be associated with bacterial infection. Reduction in oxygen availability leads to a state of hypoxia, inducing numerous cellular responses that aim to combat this stress. Importantly, hypoxia strongly augments cellular glycolysis in most cell types to compensate for the loss of aerobic respiration. Understanding how this host cell metabolic adaptation to hypoxia impacts the course of bacterial infection will identify new anti-microbial targets. This review will highlight developments in our understanding of glycolytic substrate channeling and spatiotemporal enzymatic organization in response to hypoxia, shedding light on the integral role of the hypoxia-inducible factor (HIF) during host-pathogen interactions. Furthermore, the ability of intracellular and extracellular bacteria (pathogens and commensals alike) to modulate host cellular glucose metabolism will be discussed.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glicólise
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Pflugers Arch
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Irlanda